From Albany:

Interstate 90 West to Exit 25A, To Interstate 88 West to Exit 15 (Oneonta) To County Route 28, To County Route 357 (Franklin), To County Route 21 to Walton.

From Syracuse:

Interstate 81 South, to Exit 8. (Whitney Point) to Route 206 East to Walton.

From New York City / New Jersey:

Interstate 17 West (soon to be 86) to Exit 94 (Roscoe), County Route 7 North (Cat Hollow) Route 30 West to Downsville, Route 206 West to Walton.

From Binghamton, NY:

Interstate 88 East to Exit 8 (Bainbridge) to 206 East to Walton, NY